Not a peptide, but often discussed with them
These compounds aren't peptides — they are small molecules, a nucleotide, a polyamine or a macrolide — but they come up constantly alongside peptides, so people look for them here. Each has a full profile held to the same evidence standards. They're hidden from the main library unless you switch off "Peptides only".
Blocks NNMT, which in fat cells is thought to raise NAD+ and S-adenosylmethionine availability, increasing cellular energy expenditure and reducing fat storage — shown in mice and cell culture only
Mimics ghrelin to stimulate appetite and release growth hormone and IGF-1, aiming to increase lean body mass in people losing weight from cancer
Mimics ghrelin to stimulate appetite and release growth hormone and IGF-1
Mimics ghrelin to increase pulsatile growth hormone release and raise IGF-1 around the clock, with a strong appetite effect
Shuttles electrons in energy metabolism (NAD+/NADH) and is consumed as a substrate by sirtuins, PARPs (DNA repair) and CD38; cellular levels fall with age, and raising them is the hypothesis behind all NAD+ products
Activates the GLP-1 receptor from a once-daily tablet, producing glucose-dependent insulin release, lower glucagon, slower gastric emptying and reduced appetite, without needing a peptide to be absorbed
Binds the protein FKBP12, and the pair then jams mTORC1 — the cell's main nutrient-sensing switch — so the cell shifts from growth and protein synthesis toward recycling (autophagy) and stress resistance
Induces autophagy — the cell's recycling of damaged proteins and organelles — mainly by inhibiting the acetyltransferase EP300; also stabilises DNA and RNA, supports protein translation via hypusination of eIF5A, and has anti-inflammatory…
Raises synaptic levels of three appetite- and mood-related neurotransmitters, suppressing appetite and modestly raising energy expenditure
Large proteins such as Klotho and GDF-11 are listed in the main library with a note, because they are chains of amino acids even if not peptides in the usual sense.